This antibody recognizes the ~36k Stargazin protein. Immunolabeling of the stargazin band is blocked by preadsorption with the peptide used as antigen.
Cross-Reactivity (Details)
Species reactivity (expected):Mouse. Species reactivity (tested):Rat.
Purification
Affinity Chromatography.
Immunogen
Peptide corresponding to amino acid residues from the C-terminal region of rat Stargazin, conjugated to keyhole limpet hemocyanin (KLH).
Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005, Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002).Synonyms: Neuronal voltage-gated calcium channel gamma-2 subunit, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, Voltage-dependent calcium channel gamma-2 subunit