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STK10-A antibody (pSer482, pSer486, pSer490)
STK10-A
Reactivity: Human, Mouse, Zebrafish (Danio rerio), Rat, Xenopus laevis
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-STK10-A Antibody
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Target
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STK10-A
(Serine/threonine Kinase 10 (STK10-A))
Binding Specificity
All epitopes for STK10-A antibodies
pSer482, pSer486, pSer490
Reactivity
All reactivities for STK10-A antibodies
Human, Mouse, Zebrafish (Danio rerio), Rat, Xenopus laevis
Host
All hosts for STK10-A antibodies
Rabbit
Clonality
All clonalities for STK10-A antibodies
Polyclonal
Conjugate
All conjugates for STK10-A antibodies
This STK10-A antibody is un-conjugated
Application
All applications for STK10-A antibodies
Western Blotting (WB)
Specificity
This antibody recognizes the ~120k PLKK protein phosphorylated at Ser482,486,490.
Cross-Reactivity (Details)
Species reactivity (expected):Human, Mouse, Rat and Zebrafish. Species reactivity (tested):Xenopus.
Purification
Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser482,486,490 of Xenopus polo-like kinase kinase (PLKK).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody undiluted (in aliquots) at-20 °C.
Target Details for STK10-A
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Target
STK10-A
(Serine/threonine Kinase 10 (STK10-A))
Alternative Name
PLKK1 (STK10-A Products )
Synonyms
LOK antibody, PRO2729 antibody, Gek1 antibody, Lok antibody, mKIAA4026 antibody, zgc:63495 antibody, plkk1 antibody, stk10 antibody, xPlkk1 antibody, serine/threonine kinase 10 antibody, serine/threonine kinase 10 S homeolog antibody, STK10 antibody, Stk10 antibody, stk10 antibody, stk10.S antibody
Background
Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.Synonyms: Polo-like kinase kinase 1, stk10, xPlkk1
Gene ID
373731
NCBI Accession
NP_001079164
UniProt
Q9YHC9
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