The antibody detects endogenous level of total CREB protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Peptide sequence around AA 140-144 (D-L-S-S-D) derived from Human CREB. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Boczek, Kozaczuk, Ferenc, Kosiorek, Pikula, Zylinska: "Gene expression pattern in PC12 cells with reduced PMCA2 or PMCA3 isoform: selective up-regulation of calmodulin and neuromodulin." in: Molecular and cellular biochemistry, Vol. 360, Issue 1-2, pp. 89-102, (2011) (PubMed).
Target
CREB1
(cAMP Responsive Element Binding Protein 1 (CREB1))
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Background
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.