Synuclein antibody (AA 134-138)

Catalog No. ABIN362982

Product Details anti-Synuclein Antibody

Target: Synuclein (SYU)

Binding Specificity: AA 134-138

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synuclein antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: The antibody detects endogenous level of total a-Synuclein protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogen: Peptide sequence around AA 134-138 (Q-D-Y-E-P) derived from Mouse a-Synuclein. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Application Details

Application Notes: Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

References for anti-Synuclein antibody (ABIN362982)

Zhong, Luo, Chen, Cai, Liu, Chen, Yao: "Expression and subcellular location of alpha-synuclein during mouse-embryonic development." in: Cellular and molecular neurobiology, Vol. 30, Issue 3, pp. 469-82, (2010) (PubMed).

Target Details for Synuclein

Target: Synuclein (SYU)

Alternative Name: Synuclein (SYU Products)

Background: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Takahashi T,

Molecular Weight: 18 kDa

NCBI Accession: NP_001035

UniProt: P37840