The antibody detects endogenous level of total Met protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
Immunogen
Peptide sequence around AA 1232-1236 (K-E-Y-Y-S) derived from Human Met. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
MET
Reactivity: Human, Mouse, Rat
WB, ELISA, IF, ICC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Luo, Huang, Li, Li, Sun, Zhang, Qiu, Wang: "MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met." in: PLoS ONE, Vol. 8, Issue 5, pp. e64759, (2013) (PubMed).
Li, Fu, Tie, Hu, Kong, Wu, Zheng: "miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells." in: Cancer letters, Vol. 275, Issue 1, pp. 44-53, (2009) (PubMed).
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Background
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.