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STAT3 antibody (AA 725-729)
STAT3
Reactivity: Human, Mouse, Rat
WB, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-STAT3 Antibody
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Target
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STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
Binding Specificity
All epitopes for STAT3 antibodies
AA 725-729
Reactivity
All reactivities for STAT3 antibodies
Human, Mouse, Rat
Host
All hosts for STAT3 antibodies
Rabbit
Clonality
All clonalities for STAT3 antibodies
Polyclonal
Conjugate
All conjugates for STAT3 antibodies
This STAT3 antibody is un-conjugated
Application
All applications for STAT3 antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous level of total STAT3 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen
Peptide sequence around AA 725-729 (P-M-S-P-R) derived from Human STAT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype
IgG
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Discover our top product STAT3 Primary Antibody
Alternatives
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Application Details
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Application Notes
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
References for anti-STAT3 antibody (ABIN362567)
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Cheng, Wang, Xia, Yan, Tang, Chen, Zhang, Liu, Kong, Sjöberg, Folco, Libby, Liao, Shi : "A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. " in: EMBO molecular medicine , Vol. 4 , Issue 10 , pp. 1112-25 , (2012 ) (PubMed ).
Yu, Qin, He, Wang, Fu, Liu, Guo, Liang, Dou, Han : "Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. " in: Hepatology (Baltimore, Md.) , Vol. 54 , Issue 3 , pp. 979-88 , (2011 ) (PubMed ).
Target Details for STAT3
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Target
STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
Alternative Name
STAT3 (STAT3 Products )
Synonyms
1110034C02Rik antibody, AW109958 antibody, Aprf antibody, APRF antibody, HIES antibody, Xstat3 antibody, aprf antibody, hies antibody, stat3 antibody, wu:fc15d02 antibody, wu:fl59g06 antibody, z-Stat3 antibody, signal transducer and activator of transcription 3 antibody, signal transduction and activation of transcription 3 antibody, signal transducer and activator of transcription 3, gene 1 L homeolog antibody, signal transducer and activator of transcription 3 (acute-phase response factor) antibody, STAT3 antibody, stat3 antibody, Stat3 antibody, stat3.1.L antibody
Background
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
Molecular Weight
88 kDa
NCBI Accession
NP_003141
UniProt
P40763
Pathways
JAK-STAT Signaling , RTK Signaling , Interferon-gamma Pathway , Neurotrophin Signaling Pathway , Dopaminergic Neurogenesis , Response to Growth Hormone Stimulus , Carbohydrate Homeostasis , Stem Cell Maintenance , Hepatitis C , Protein targeting to Nucleus , Feeding Behaviour , CXCR4-mediated Signaling Events , Signaling of Hepatocyte Growth Factor Receptor
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