AHSA1 antibody

Catalog No. ABIN361854

Product Details anti-AHSA1 Antibody

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AHSA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Detects ~ 38 kDa.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein A Purified

Immunogen: Recombinant Full Length Mouse Aha1 Protein

Application Details

Application Notes:

• WB (1:1000)
• ICC/IF (1:60)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μl/ml of ABIN361853 was sufficient for detection of Aha1 in 10 μg of mixed human cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

References for anti-AHSA1 antibody (ABIN361854)

Echeverría, Bernthaler, Dupuis, Mayer, Picard: "An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine." in: PLoS ONE, Vol. 6, Issue 10, pp. e26044, (2011) (PubMed).

Target Details for AHSA1

Target: AHSA1 (Activator of HSP90 ATPase Activity 1 (AHSA1))

Alternative Name: AHA1 (AHSA1 Products)

Synonyms: ahsa1 antibody, MGC52884 antibody, MGC132147 antibody, MGC80312 antibody, AHSA1 antibody, MGC89589 antibody, wu:fb83b05 antibody, zgc:136821 antibody, zgc:56075 antibody, AHA1 antibody, C14orf3 antibody, p38 antibody, BC023857 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 S homeolog antibody, activator of Hsp90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 L homeolog antibody, activator of HSP90 ATPase activity 1 antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 antibody, AHA1, activator of heat shock protein ATPase homolog 1a antibody, AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) antibody, AHA1, activator of heat shock protein ATPase 1 antibody, ahsa1.S antibody, AHSA1 antibody, ahsa1.L antibody, ahsa1 antibody, ahsa1a antibody, Ahsa1 antibody

Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Gene ID: 217737

NCBI Accession: NP_666148

UniProt: Q8BK64