DDC antibody

Catalog No. ABIN361424

Product Details anti-DDC Antibody

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivity: Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDC antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Specific for the ~55k DDC protein.

Cross-Reactivity: Rat (Rattus)

Predicted Reactivity: Bovine

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: SDS denatured, recombinant bovine aromatic DOPA decarboxylase expressed in E. coli and purified from inclusion bodies

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Alternative Name: DDC (DDC Products)

Background: DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC, DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002, Berry et al., 1996, Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001, Zhu et al., 2000, Zhu et al., 1999). Anti-DOPA Decarboxylase Western blot of rat adrenal medulla. As shown in the autoradiograph, the antibody is specific for the ~55k DDC protein.

Molecular Weight: '55 kDa

Gene ID: 280762

UniProt: P27718

Pathways: Dopaminergic Neurogenesis