Retinoid X Receptor beta antibody

Catalog No. ABIN361387

Product Details anti-Retinoid X Receptor beta Antibody

Target: Retinoid X Receptor beta (RXRB) (Retinoid X Receptor, beta (RXRB))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoid X Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Specific for the ~48k RXR-( protein.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Purification: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the hinge region conjugated to KLH

Clone: 147

Isotype: IgG1

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for Retinoid X Receptor beta

Target: Retinoid X Receptor beta (RXRB) (Retinoid X Receptor, beta (RXRB))

Alternative Name: RXRB (RXRB Products)

Background: Retinoic acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRa, ß and (), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). Anti-Human Retinoid X Receptor Antibody, (-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RXR-ß protein.

Molecular Weight: '48 kDa

Gene ID: 6257

UniProt: P28702

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway