THRB antibody (N-Term)

Catalog No. ABIN361385

Product Details anti-THRB Antibody

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Binding Specificity: N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Specific for the ~55k TR-ß protein.

Cross-Reactivity: Human

Purification: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Clone: 2386

Isotype: IgG1

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: THRB (THRB Products)

Synonyms: C-ERBA-2 antibody, C-ERBA-BETA antibody, ERBA2 antibody, GRTH antibody, NR1A2 antibody, PRTH antibody, THR1 antibody, THRB1 antibody, THRB2 antibody, Nr1a2 antibody, T3R[b] antibody, T3Rbeta antibody, Thrb1 antibody, Thrb2 antibody, c-erbAbeta antibody, TR-beta antibody, TR[b]1 antibody, fj24f03 antibody, trb antibody, wu:fj24f03 antibody, CTR BETA 2 antibody, TR-BETA antibody, LOC734147 antibody, thrb antibody, THRB antibody, C-erba-beta antibody, RATT3REC antibody, T3rec antibody, TRbeta antibody, THR antibody, TRbeta1 antibody, thyroid hormone receptor beta antibody, thyroid hormone receptor, beta antibody, thyroid hormone receptor, beta S homeolog antibody, thyroid hormone receptor, beta L homeolog antibody, THRB antibody, Thrb antibody, thrb antibody, thrb.S antibody, thrb.L antibody

Background: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, -Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~58k TR- protein.

Molecular Weight: '55 kDa

Gene ID: 7068

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound