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THRA antibody (N-Term)
THRA
Reactivity: Human
WB
Host: Mouse
Monoclonal
2103
unconjugated
Product Details anti-THRA Antibody
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Target
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THRA
(Thyroid Hormone Receptor, alpha (THRA))
Binding Specificity
All epitopes for THRA antibodies
N-Term
Reactivity
All reactivities for THRA antibodies
Human
Host
All hosts for THRA antibodies
Mouse
Clonality
All clonalities for THRA antibodies
Monoclonal
Conjugate
All conjugates for THRA antibodies
This THRA antibody is un-conjugated
Application
All applications for THRA antibodies
Western Blotting (WB)
Specificity
Specific for the ~50k TR-a1 and the ~58k TR-a2 proteins.
Cross-Reactivity
Human, Rat (Rattus)
Predicted Reactivity
canine, mouse, non-human primate
Purification
Protein G purified culture supernatant
Immunogen
Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH
Clone
2103
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Storage
-20 °C
Target Details for THRA
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Target
THRA
(Thyroid Hormone Receptor, alpha (THRA))
Alternative Name
THRA (THRA Products )
Synonyms
AR7 antibody, CHNG6 antibody, EAR7 antibody, ERB-T-1 antibody, ERBA antibody, ERBA1 antibody, NR1A1 antibody, THRA1 antibody, THRA2 antibody, c-ERBA-1 antibody, C-ERBA-ALPHA antibody, TRalpha antibody, c-erba antibody, erba antibody, nr1a1-A antibody, thra-A antibody, thra1 antibody, TR[a]1 antibody, nr1a1 antibody, thra antibody, thral antibody, tra antibody, tra1 antibody, wu:fb59g07 antibody, Thra1 antibody, 6430529J03Rik antibody, AW259572 antibody, Erba antibody, Nr1a1 antibody, Rvr antibody, T3R[a] antibody, T3Ralpha antibody, Thra2 antibody, C-ERBA ALPHA1 antibody, Thra antibody, fTHRalphaA antibody, nr1a1-a antibody, thyroid hormone receptor, alpha antibody, thyroid hormone receptor, alpha L homeolog antibody, thyroid hormone receptor alpha a antibody, thyroid hormone receptor alpha antibody, thyroid hormone receptor alpha-A antibody, THRA antibody, thra.L antibody, thraa antibody, Thra antibody, tr-alpha antibody, LOC109641414 antibody
Background
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.
Molecular Weight
50/58 kDa
Gene ID
7067
UniProt
P10827
Pathways
Nuclear Receptor Transcription Pathway , Steroid Hormone Mediated Signaling Pathway , Sensory Perception of Sound , Cellular Response to Molecule of Bacterial Origin , Regulation of Lipid Metabolism by PPARalpha , Regulation of Muscle Cell Differentiation , Maintenance of Protein Location , Skeletal Muscle Fiber Development
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