Nuclear Stain of Multiple Gene Products Including Nup62, Nup133 antibody

Catalog No. ABIN361356

Product Details

Target: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Reactivity: Saccharomyces cerevisiae

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (IF)

Specificity: Reacts with a nuclear pore complex protein.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: Protein G purified culture supernatant

Immunogen: Yeast nuclear preparations

Clone: 39C7

Isotype: IgG1

Application Details

Application Notes: Recommended Dilution: IF: 1:50-1:100 Quality Control: Immunofluorescence performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: total IgG fraction + 10 mM Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Background: The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993, Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).