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MAP4K3 antibody (C-Term)

MAP4K3 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN360428
  • Target See all MAP4K3 Antibodies
    MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3))
    Binding Specificity
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 59
    • 30
    • 16
    Human
    Host
    • 57
    • 2
    Rabbit
    Clonality
    • 57
    • 2
    Polyclonal
    Conjugate
    • 24
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This MAP4K3 antibody is un-conjugated
    Application
    • 42
    • 33
    • 32
    • 20
    • 6
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to GLK.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GLK.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MAP4K3 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/250 - 1/500. Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MAP4K3 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3))
    Alternative Name
    MAP4K3 (MAP4K3 Products)
    Synonyms
    GLK antibody, MAPKKKK3 antibody, MEKKK 3 antibody, MEKKK3 antibody, RAB8IPL1 antibody, 4833416M01Rik antibody, 4833416M07Rik antibody, 9530052P13Rik antibody, Glk antibody, mitogen-activated protein kinase kinase kinase kinase 3 antibody, MAP4K3 antibody, Map4k3 antibody
    Background
    GLK is a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).Synonyms: Germinal center kinase-related protein kinase, MAPK, MAPK/ERK kinase kinase kinase 3, MEKKK 3, Mitogen-activated protein kinase kinase kinase kinase 3, RAB8IPL1
    Gene ID
    8491, 9606
    UniProt
    Q8IVH8
    Pathways
    MAPK Signaling
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