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PAK3 antibody (Middle Region)

PAK3 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN360320
  • Target See all PAK3 Antibodies
    PAK3
    Binding Specificity
    • 15
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 70
    • 29
    • 18
    • 3
    Human
    Host
    • 65
    • 5
    • 2
    Rabbit
    Clonality
    • 67
    • 6
    Polyclonal
    Conjugate
    • 33
    • 6
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAK3 antibody is un-conjugated
    Application
    • 60
    • 40
    • 32
    • 13
    • 13
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to PAK3.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human PAK3.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PAK3 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    PAK3
    Alternative Name
    PAK3 (PAK3 Products)
    Synonyms
    CDKN1A antibody, MRX30 antibody, MRX47 antibody, OPHN3 antibody, PAK3beta antibody, bPAK antibody, hPAK3 antibody, PAK-3 antibody, Pak65alpha antibody, Pak65beta antibody, Stk4 antibody, beta-PAK antibody, XPak3 antibody, bpak antibody, cdkn1a antibody, mrx30 antibody, mrx47 antibody, ophn3 antibody, pak3 antibody, pak3-A antibody, pak3beta antibody, p21 (RAC1) activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 antibody, p21 protein (Cdc42/Rac)-activated kinase 3 L homeolog antibody, PAK3 antibody, Pak3 antibody, pak3.L antibody
    Background
    PAK3, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. PAK3 interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. It shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK. This protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. PAK3 is autophosphorylated when activated by CDC42/p21. Defects in PAK3 are the cause of non-specific X-linked nonsyndromic mental retardation type 30 (MRX30). The protein structure contains 1 CRIB domain.Synonyms: Beta-PAK, OPHN3, Oligophrenin-3, PAK 3, PAK beta, PAK-3, Serine/threonine-protein kinase PAK 3, p21-activated kinase 3
    Gene ID
    5063, 9606
    UniProt
    O75914
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