DCXR antibody (Middle Region)

Catalog No. ABIN359606

Product Details anti-DCXR Antibody

Target: DCXR (Dicarbonyl/L-Xylulose Reductase (DCXR))

Binding Specificity: Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCXR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human and Mouse DCXR. Other species not tested.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 79-106 amino acids from the Central region of Human DCXR.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000
Western blotting: 1/50 - 1/100
Immunohistochemistry on Paraffin Sections: 1/50-1/100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for DCXR

Target: DCXR (Dicarbonyl/L-Xylulose Reductase (DCXR))

Alternative Name: L-Xylulose Reductase (DCXR Products)

Synonyms: DCR antibody, HCR2 antibody, HCRII antibody, KIDCR antibody, P34H antibody, SDR20C1 antibody, XR antibody, dcxr antibody, DCXR antibody, DER antibody, 0610038K04Rik antibody, 1810027P18Rik antibody, glb antibody, wu:fa12f09 antibody, zgc:111977 antibody, GLB antibody, dicarbonyl and L-xylulose reductase antibody, dicarbonyl/L-xylulose reductase antibody, dicarbonyl L-xylulose reductase antibody, L-xylulose reductase antibody, L-xylulose reductase, putative antibody, dicarbonyl/L-xylulose reductase L homeolog antibody, DCXR antibody, dcxr antibody, Dcxr antibody, CNL05930 antibody, NCU09041 antibody, AOR_1_494194 antibody, VDBG_02657 antibody, CGB_D1070C antibody, dcxr.L antibody

Background: DCXR is an enzyme that has both diacetyl reductase and L-xylulose reductase activities. Function: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. Cellular Location: Membrane, Peripheral membrane protein (By similarity). Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). Tissue Location: Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.Synonyms: Carbonyl reductase II, DCXR, Dicarbonyl/L-xylulose reductase, Kidney dicarbonyl reductase, P34H, Sperm surface protein P34H, XR

Molecular Weight: 25913 Da (calculated)

Gene ID: 51181, 9606

UniProt: Q7Z4W1

Pathways: Glycosaminoglycan Metabolic Process, Monocarboxylic Acid Catabolic Process