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DKK4 antibody (N-Term)

DKK4 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN357073
  • Target See all DKK4 Antibodies
    DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
    Binding Specificity
    • 17
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 7-36, N-Term
    Reactivity
    • 54
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 56
    • 3
    • 1
    Rabbit
    Clonality
    • 58
    • 2
    Polyclonal
    Conjugate
    • 23
    • 9
    • 7
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DKK4 antibody is un-conjugated
    Application
    • 52
    • 35
    • 27
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequence
    DKK4
    Specificity
    This antibody detects DKK4 at N-term.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    KLH conjugated synthetic peptide between 7~36 amino acids from the N-terminal region of Human DKK4
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DKK4 Primary Antibody
  • Application Notes
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
    Alternative Name
    Dickkopf-4 (DKK4) (DKK4 Products)
    Synonyms
    DKK-4 antibody, Dkk-4 antibody, RGD1563172 antibody, dickkopf WNT signaling pathway inhibitor 4 antibody, DKK4 antibody, Dkk4 antibody
    Background
    DKK4, like DKK1, DKK2, and DKK3, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis detected no expression of DKK4, but RT-PCR analysis detected DKK4 expression in cerebellum, T-cell, esophagus, and lung cDNA libraries. DKK4 blocks Xenopus Wnt8, Wnt3a, and Wnt2b, but not Dsh or Fz8, induction of a secondary axis in frog embryos, indicating that DKKs antagonize WNT function upstream of WNT receptors.Synonyms: Dickkopf-related protein 4, Dkk-4
    Molecular Weight
    24875 Da
    Gene ID
    27121, 9606
    UniProt
    Q9UBT3
    Pathways
    WNT Signaling
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