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DKK3 antibody (N-Term)

Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN357071
  • Target See all DKK3 Antibodies
    DKK3
    Binding Specificity
    • 15
    • 9
    • 9
    • 8
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 54
    • 35
    • 17
    • 14
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 66
    • 5
    • 2
    • 1
    Rabbit
    Clonality
    • 67
    • 7
    Polyclonal
    Conjugate
    • 33
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DKK3 antibody is un-conjugated
    Application
    • 55
    • 38
    • 29
    • 13
    • 13
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects DKK3 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DKK3.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DKK3 Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DKK3
    Alternative Name
    Dickkopf-3 (DKK3) (DKK3 Products)
    Synonyms
    REIC antibody, RIG antibody, reic antibody, dkk-3 antibody, AW061014 antibody, C87148 antibody, Reic antibody, p29 antibody, dickkopf WNT signaling pathway inhibitor 3 antibody, dickkopf WNT signaling pathway inhibitor 3 S homeolog antibody, DKK3 antibody, dkk3 antibody, dkk3.S antibody, Dkk3 antibody
    Background
    DKK3, like DKK1, DKK2, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed wide expression of the DKK3 transcript, with highest expression in heart, brain, and spinal cord. In situ hybridization reveals highest expression in mouse brain, eye, and heart.Synonyms: Dickkopf-related protein 3, Dkk-3, REIC
    Molecular Weight
    38291 Da
    Gene ID
    27122
    NCBI Accession
    NP_001018067
    UniProt
    Q9UBP4
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