HNMT antibody (N-Term)

Catalog No. ABIN356933

Product Details anti-HNMT Antibody

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNMT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody detects HNMT at N-term.

Purification: Protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human HNMT.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000. Western blot 1: 50 - 1: 100. Immunohistochemistry 1: 10 - 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for HNMT

Target: HNMT (Histamine N-Methyltransferase (HNMT))

Alternative Name: HNMT / HMT (HNMT Products)

Synonyms: HMT antibody, HNMT-S1 antibody, HNMT-S2 antibody, hmt antibody, hnmt antibody, hnmt-s1 antibody, hnmt-s2 antibody, zgc:100917 antibody, HNMT antibody, 1500031F01Rik antibody, AI788969 antibody, HMT A antibody, hnmt-a antibody, hnmt-b antibody, histamine N-methyltransferase antibody, histamine N-methyltransferase S homeolog antibody, histamine N-methyltransferase-like antibody, histamine N-methyltransferase L homeolog antibody, HNMT antibody, hnmt.S antibody, hnmt antibody, Hnmt antibody, LOC100228106 antibody, hnmt.L antibody

Background: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.Synonyms: Histamine N-methyltransferase

Molecular Weight: 33295 Da

Gene ID: 3176, 9606

UniProt: P50135