Cadherin 8 antibody (N-Term)

Catalog No. ABIN356866

Product Details anti-Cadherin 8 Antibody

Target: Cadherin 8 (CDH8)

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody is specific to CDH8 (N-term).

Purification: Protein A Chromatography followed by Peptide Affinity purification.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CDH8.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blot: 1/50-1/100. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-Cadherin 8 antibody (ABIN356866)

Kher, Sha, Escobar, Andreoli, Wang, Xu, Wandinger-Ness, Bacallao: "Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture." in: American journal of physiology. Cell physiology, Vol. 301, Issue 1, pp. C99-C105, (2011) (PubMed).

Target Details for Cadherin 8

Target: Cadherin 8 (CDH8)

Alternative Name: Cadherin-8 (CDH8 Products)

Synonyms: AI851472 antibody, cad8 antibody, cadherin-8 antibody, Nbla04261 antibody, cadherin 8 antibody, cadherin 8, type 2 antibody, Cdh8 antibody, CDH8 antibody

Background: CDH8 is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.Synonyms: CDH8

Gene ID: 1006, 9606

UniProt: P55286

Pathways: Cell-Cell Junction Organization