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JMJD4 antibody (C-Term)

JMJD4 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN356562
  • Target See all JMJD4 products
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Binding Specificity
    • 8
    • 8
    • 5
    • 4
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 26
    • 11
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 26
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    This JMJD4 antibody is un-conjugated
    Application
    • 26
    • 15
    • 8
    • 4
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody will recognize JMJD4 (C-term). It Cross reacts with Mouse (Predicted by 100 % Antigen Homology).
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human JMJD4.
    Isotype
    Ig Fraction
  • Application Notes
    ELISA: 1/1,000. Western Blot: 1/250-1/500. Immunohistochemistry: 1/10approx. 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    JMJD4 (Jumonji Domain Containing 4 (JMJD4))
    Alternative Name
    JMJD4 (JMJD4 Products)
    Synonyms
    JMJD4 antibody, 6430559I23 antibody, RGD1307186 antibody, jumonji domain containing 4 antibody, jumonji domain containing 4 L homeolog antibody, JMJD4 antibody, jmjd4.L antibody, Jmjd4 antibody
    Background
    Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: JmjC domain-containing protein 4, Jumonji domain-containing protein 4
    Gene ID
    65094, 9606
    UniProt
    Q9H9V9
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