STAM 1, 2 (Internal Region) antibody
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- Target
- STAM 1, 2
- Binding Specificity
- Internal Region
- Reactivity
- Human
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Host
-
Sheep
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
- Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificity
- Specific for STAM1 & 2.
- Cross-Reactivity
- Human, Mouse, Rat
- Cross-Reactivity (Details)
- Other species not yet tested.
- Purification
- IgG
- Immunogen
- A synthetic peptide from the internal part of human STAM 1, 2 (STAM-1, STAM-2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including rat, mouse, zebra fish and xenopus.
- Isotype
- IgG
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- Application Notes
- IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
- Handling Advice
- Avoid freeze and thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
- Expiry Date
- 12 months
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- Target
- STAM 1, 2
- Background
- STAM1: FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development. SUBUNIT: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH. TISSUE SPECIFICITY: Ubiquitously expressed. STAM2: FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development. SUBUNIT: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C. TISSUE SPECIFICITY: Ubiquitously expressed.,Signal Transduction,STAM1, STAM-1, STAM2, STAM-2, Signal transducing adapter molecule 1, Signal transducing adapter molecule 2, HBP, Hrs-binding protein
- UniProt
- Q92783
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