CHMP6 antibody (C-Term)

Catalog No. ABIN350233

Product Details anti-CHMP6 Antibody

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Sheep

Clonality: Polyclonal

Conjugate: This CHMP6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for CHMP6.

Cross-Reactivity: Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from the c-terminal region of mouse CHMP6 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with rat's.

Isotype: IgG

Application Details

Application Notes: IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for CHMP6

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Alternative Name: CHMP6 (CHMP6 Products)

Synonyms: chmp6 antibody, vps20 antibody, 2400004G01Rik antibody, VPS20 antibody, RGD1565325 antibody, chmp6l antibody, flj11749l antibody, wu:fb79d02 antibody, zgc:110067 antibody, charged multivesicular body protein 6 antibody, charged multivesicular body protein 6 L homeolog antibody, charged multivesicular body protein 6 S homeolog antibody, charged multivesicular body protein 6b antibody, LOC100280982 antibody, chmp6.L antibody, chmp6.S antibody, CHMP6 antibody, chmp6 antibody, Tsp_08316 antibody, Chmp6 antibody, chmp6b antibody

Background: FUNCTION: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex, it probably serves as an acceptor for ESCRT-II complex on endosomal membranes. SUBUNIT: Component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3/VPS24, CHMP4A/SHAX2, CHMP4B/SHAX1, CHMP4C/SHAX3, CHMP5/SNF7DC2 and CHMP6/VPS20. In the complex, it interacts directly with CHMP4A, CHMP4B and CHMP4C. Interacts directly with SNF8, VPS25 and VPS36 components of the ESCRT-II complex. SUBCELLULAR LOCATION: Intracytoplasmic membrane. Endosome membrane, Lipid-anchor . Note: Localizes to endosomal membranes.,Vesicle Protein Sorting,Charged multivesicular body protein 6, Chromatin-modifying protein 6

UniProt: P0C0A3