CHMP3 antibody (N-Term)

Catalog No. ABIN350226

Product Details anti-CHMP3 Antibody

Target: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHMP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificity: Specific for CHMP3.

Cross-Reactivity: Human, Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from the n-terminal of human VPS24 conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in rat and mouse.

Isotype: IgG

Application Details

Application Notes: IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for CHMP3

Target: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Alternative Name: VPS24 (CHMP3 Products)

Synonyms: CG9779 antibody, Dmel\\CG9779 antibody, Vps24 antibody, dvps24 antibody, vps24 antibody, VPS24 antibody, CHMP3 antibody, GB15107 antibody, wu:fb47g01 antibody, zgc:76972 antibody, NEDF antibody, 25.1 antibody, 4921505F14Rik antibody, 9130011K15Rik antibody, CGI-49 antibody, D6Ertd286e antibody, Vacuolar protein sorting 24 antibody, charged multivesicular body protein 3 antibody, SNF7 family protein antibody, hypothetical protein antibody, neuroendocrine differentiation factor, putative antibody, charged multivesicular body protein 3 S homeolog antibody, Vps24 antibody, chmp3 antibody, VPS24.2 antibody, CpipJ_CPIJ004098 antibody, PGTG_02107 antibody, LOC5569267 antibody, Smp_032150 antibody, CHMP3 antibody, LOC410607 antibody, Chmp3 antibody, chmp3.S antibody

Background: FUNCTION: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. Required for sorting/trafficking of EGF receptor. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins. SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane, Lipid-anchor. TISSUE SPECIFICITY: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,Vesicle Protein Sorting,Chromatin-modifying protein 3, Vacuolar protein-sorting-associated protein 24, hVps24, Neuroendocrine differentiation factor, Charged multivesicular body protein 3, NEDF

UniProt: Q9Y3E7