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SERPINB2 antibody (Internal Region)

Rockland 600-401-b22 SERPINB2 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Rockland
Catalog No. ABIN349627
Supplier Product No.: 600-401-b22
  • Target See all SERPINB2 Antibodies
    SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
    Binding Specificity
    • 15
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    • 47
    • 12
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 46
    • 8
    • 1
    • 1
    Rabbit
    Clonality
    • 50
    • 5
    Polyclonal
    Conjugate
    • 29
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SERPINB2 antibody is un-conjugated
    Application
    • 29
    • 17
    • 13
    • 13
    • 12
    • 7
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Supplier Product No.
    600-401-b22
    Supplier
    Rockland
    Purpose
    Plasminogen Activator Inhibitor 2 Antibody
    Cross-Reactivity (Details)
    This affinity-purified antibody is directed against human PAI-2 protein.
    Characteristics
    Synonyms: rabbit anti-PAI-2 antibody, rabbit anti-plasminogen activator inhibitor 2 antibody, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2, Serpin B2, serpin peptidase inhibitor, PAI2, PLANH2
    Purification
    The product was affinity purified from monospecific antiserum by immunoaffinity purification.
    Sterility
    Sterile filtered
    Immunogen

    Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human PAI-2 protein.

    Immunogen Type: Conjugated Peptide

    Isotype
    IgG
    Top Product
    Discover our top product SERPINB2 Primary Antibody
  • Application Notes

    Immunohistochemistry Dilution: 10 μg/mL

    Application Note: This affinity purified antibody has been tested for use in ELISA, Immunochemistry, and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to PAI-2 protein by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:500 - 1:2,000

    ELISA Dilution: 1:100,000 - 150,000

    Other: User Optimized

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.2 mg/mL
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
    Expiry Date
    12 months
  • Godtfredsen, Sidelmann, Dolleris, Jørgensen, Johansen, Pedersen, Palarasah, Gram: "Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).

  • Target
    SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
    Alternative Name
    SERPINB2 (SERPINB2 Products)
    Target Type
    Amino Acid
    Background
    Background: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60- kDa, secreted, extracellular, glycosylated form and a 43- kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.
    Gene ID
    5055, 4505595
    UniProt
    P05120
    Pathways
    Autophagy
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