SERPINB2 antibody (Internal Region)
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- Target See all SERPINB2 Antibodies
- SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SERPINB2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Supplier Product No.
- 600-401-b22
- Supplier
- Rockland
- Purpose
- Plasminogen Activator Inhibitor 2 Antibody
- Cross-Reactivity (Details)
- This affinity-purified antibody is directed against human PAI-2 protein.
- Characteristics
- Synonyms: rabbit anti-PAI-2 antibody, rabbit anti-plasminogen activator inhibitor 2 antibody, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2, Serpin B2, serpin peptidase inhibitor, PAI2, PLANH2
- Purification
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
- Sterility
- Sterile filtered
- Immunogen
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human PAI-2 protein.
Immunogen Type: Conjugated Peptide
- Isotype
- IgG
- Top Product
- Discover our top product SERPINB2 Primary Antibody
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- Application Notes
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Immunohistochemistry Dilution: 10 μg/mL
Application Note: This affinity purified antibody has been tested for use in ELISA, Immunochemistry, and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to PAI-2 protein by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1:500 - 1:2,000
ELISA Dilution: 1:100,000 - 150,000
Other: User Optimized
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.2 mg/mL
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide - Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Expiry Date
- 12 months
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Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).
: "
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Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).
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- Target
- SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))
- Alternative Name
- SERPINB2 (SERPINB2 Products)
- Target Type
- Amino Acid
- Background
- Background: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60- kDa, secreted, extracellular, glycosylated form and a 43- kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.
- Gene ID
- 5055, 4505595
- UniProt
- P05120
- Pathways
- Autophagy
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