THRB antibody (Isoform 1, N-Term)

Catalog No. ABIN349600

Product Details anti-THRB Antibody

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Binding Specificity: Isoform 1, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THRB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Characteristics: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the of human THRB protein.

Isotype: IgG

Application Details

Application Notes: This affinity purified antibody has been tested for use in ELISA and western blotting.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-THRB antibody (ABIN349600)

Fozzatti, Park, Zhao, Willingham, Cheng: "Oncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer." in: PLoS ONE, Vol. 8, Issue 6, pp. e67954, (2017) (PubMed).

Zhao, Zhu, Won Park, Fozzatti, Willingham, Cheng: "Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptor." in: Endocrinology, Vol. 153, Issue 10, pp. 5090-100, (2012) (PubMed).

Mascanfroni, Montesinos, Alamino, Susperreguy, Nicola, Ilarregui, Masini-Repiso, Rabinovich, Pellizas: "Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9569-82, (2010) (PubMed).

Target Details for THRB

Target: THRB (Thyroid Hormone Receptor, beta (THRB))

Alternative Name: Thyroid Hormone Receptor beta 1 (THRB Products)

Synonyms: C-ERBA-2 antibody, C-ERBA-BETA antibody, ERBA2 antibody, GRTH antibody, NR1A2 antibody, PRTH antibody, THR1 antibody, THRB1 antibody, THRB2 antibody, Nr1a2 antibody, T3R[b] antibody, T3Rbeta antibody, Thrb1 antibody, Thrb2 antibody, c-erbAbeta antibody, TR-beta antibody, TR[b]1 antibody, fj24f03 antibody, trb antibody, wu:fj24f03 antibody, CTR BETA 2 antibody, TR-BETA antibody, LOC734147 antibody, thrb antibody, THRB antibody, C-erba-beta antibody, RATT3REC antibody, T3rec antibody, TRbeta antibody, THR antibody, TRbeta1 antibody, thyroid hormone receptor beta antibody, thyroid hormone receptor, beta antibody, thyroid hormone receptor, beta S homeolog antibody, thyroid hormone receptor, beta L homeolog antibody, THRB antibody, Thrb antibody, thrb antibody, thrb.S antibody, thrb.L antibody

Background: Anti-Thyroid Hormone Receptor ß1 (TRB1) antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). This TRB1 antibody is ideal for Immunology, Thyroid and Signal Tranduction research.
Synonyms: Thyroid hormone receptor beta TRB1 TR beta signaling c-erbA-beta c-erbA-2 Nuclear receptor subfamily 1 group A member 2

Gene ID: 7068, 40806162

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound