Prosaposin antibody
-
- Target See all Prosaposin (PSAP) Antibodies
- Prosaposin (PSAP)
-
Reactivity
- Human
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This Prosaposin antibody is un-conjugated
-
Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Specificity
- Reacts with human Saposin-B
- Cross-Reactivity (Details)
- May cross react with proteins from other species due to sequence homology
- Purification
- Antiserum
- Immunogen
- Synthetic peptide derived from an internal domain of human PSAP
- Isotype
- IgG
- Top Product
- Discover our top product PSAP Primary Antibody
-
-
- Application Notes
-
Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC1:200 - 1:1 000 WB1:500 - 1:5 000 - Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Must be reconstituted in distilled water.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 24 months
-
- Target
- Prosaposin (PSAP)
- Alternative Name
- Proactivator Polypeptide Domain Saposin-B (PSAP) (PSAP Products)
- Synonyms
- GLBA antibody, SAP1 antibody, AI037048 antibody, SGP-1 antibody, SGP1A antibody, cb759 antibody, wu:fa14a06 antibody, wu:fb36e02 antibody, wu:fb58g07 antibody, PSAP antibody, PSP-A antibody, SFTPA1B antibody, SP-A antibody, prosaposin antibody, surfactant protein A1 antibody, PSAP antibody, Psap antibody, psap antibody, LOC100011417 antibody, LOC100304726 antibody, LOC100526719 antibody, SFTPA1 antibody
- Background
- The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator.
- Gene ID
- 5660
- UniProt
- P07602
- Pathways
- Positive Regulation of Endopeptidase Activity
-