AGR2+AGR3 antibody
Reactivity: Human
WB, ICC, IHC (p)
Host: Mouse
Monoclonal
AGR3-4
unconjugated
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- Target See all AGR2+AGR3 products
- AGR2+AGR3
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This AGR2+AGR3 antibody is un-conjugated
- Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- The antibody AGR3.4 recognizes the PLMII epitope of AGR3 (AG3) and AGR2 (AG2) proteins (19-20 kDa), secreted cytoplasmic proteins which can serve as markers of carcinogenesis.
- Cross-Reactivity (Details)
- Human, Other species Not tested
- Purification
- Purified by protein-A affinity chromatography.
- Purity
- > 95 % (by SDS-PAGE)
- Immunogen
- Purified human AGR3 protein
- Clone
- AGR3-4
- Isotype
- IgG1
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- Application Notes
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Immunohistochemistry (paraffin sections): Recommended dilution: 5 μg/mL, Positive tissue: human colon.
Western blotting: Recommended dilution: 1 μg/mL, positive control: T47D breast cancer cell line, negative control: H1299 lung carcinoma cell line.
Immunocytochemistry: Recommended dilution: 1 μg/mL, positive control: T47D breast cancer cell line, negative control: H1299 lung carcinoma cell line. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Do not freeze.
- Storage
- 4 °C
- Storage Comment
- Store at 2-8°C. Do not freeze.
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- Target
- AGR2+AGR3
- Abstract
- AGR2+AGR3 Products
- Synonyms
- AG3 antibody, BCMP11 antibody, HAG3 antibody, PDIA18 antibody, hAG-3 antibody, E030025L21Rik antibody, Gm888 antibody, anterior gradient 3, protein disulphide isomerase family member antibody, anterior gradient 3 antibody, AGR3 antibody, Agr3 antibody
- Background
- AGR2 (Anterior Gradient 2), also known as AG2 (hAG-2, HAG2 in human), or GOB-4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG-3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours, AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development.,AG2, AG3, HAG2, HAG3
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