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HSP90 alpha/beta antibody (N-Term)

HSP90 alpha/beta Reactivity: Human, Mouse, Cow WB, IHC (p) Host: Mouse Monoclonal MBH90AB unconjugated
Catalog No. ABIN343706
  • Target See all HSP90 alpha/beta products
    HSP90 alpha/beta (Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta))
    Binding Specificity
    • 12
    • 10
    • 2
    • 1
    • 1
    N-Term
    Reactivity
    • 33
    • 26
    • 26
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Cow
    Host
    • 16
    • 14
    • 3
    Mouse
    Clonality
    • 16
    • 16
    Monoclonal
    Conjugate
    • 10
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    This HSP90 alpha/beta antibody is un-conjugated
    Application
    • 33
    • 30
    • 15
    • 8
    • 6
    • 6
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    The antibody MBH90AB recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.
    Cross-Reactivity (Details)
    Human, Mouse, Bovine, Other not determined
    Purification
    Purified by protein-A affinity chromatography.
    Purity
    > 95 % (by SDS-PAGE)
    Immunogen
    Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.
    Clone
    MBH90AB
    Isotype
    IgG1
  • Application Notes
    Western blotting: Recommended dilution: 1 μg/mL.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    HSP90 alpha/beta (Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta))
    Alternative Name
    Hsp90 alpha,beta (HSP90 alpha/beta Products)
    Background
    Hsp90 (heat shock protein 90) is one of the most abundant chaperones in the cytosol of eukaryotic cells. It interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis. There are two isoforms, alpha and beta, of vertebrate Hsp90. Whereas Hsp90 beta is expressed constitutively to a high level, Hsp90 alpha is stress-inducible and is overexpressed in many cancerous cells.,HSP90A, HSP90B, LAP-2, LAP2, EL52
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