LBP antibody

Catalog No. ABIN343174

Product Details anti-LBP Antibody

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This LBP antibody is un-conjugated

Application: ELISA

Specificity: Mouse LBP. The antibody don't blocks LPS binding to membrane bound CD14.

Cross-Reactivity: Rat (Rattus)

Purification: Protein A affinity column

Immunogen: native mouse LBP

Clone: BiG35

Isotype: IgG2a

Application Details

Application Notes: ELISA, LBP inhibition studies, Western Blot. Non inhibition of LPS binding to membrane bound CD14, Binding titre at - ELISA: more than1:20.000

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute with bidistilled water

Concentration: 1 mg/mL

Buffer: PBS, pH 7.18

Preservative: Without preservative

Storage: -20 °C,-80 °C

References for anti-LBP antibody (ABIN343174)

Stamme, Mueller, Hamann, Gutsmann, Seydel: "Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein." in: American journal of respiratory cell and molecular biology, Vol. 27, Issue 3, pp. 353-60, (2002) (PubMed).

Gutsmann, Mueller, Carroll, MacKenzie, Wiese, Seydel: "Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells." in: Infection and immunity, Vol. 69, Issue 11, pp. 6942-50, (2001) (PubMed).

Hamann, Schumann, Flad, Brade, Rietschel, Ulmer: "Binding of lipopolysaccharide (LPS) to CHO cells does not correlate with LPS-induced NF-kappaB activation." in: European journal of immunology, Vol. 30, Issue 1, pp. 211-6, (2000) (PubMed).

Target Details for LBP

Target: LBP (Lipopolysaccharide Binding Protein (LBP))

Alternative Name: Lipopolysaccharide (LPS)-Binding Protein (LBP) (LBP Products)

Synonyms: BPIFD2 antibody, Bpifd2 antibody, Ly88 antibody, LPSBP antibody, LBP antibody, lipopolysaccharide binding protein antibody, lipopolysaccharide-binding protein antibody, LBP antibody, Lbp antibody, LOC100472839 antibody

Background: Background: Natural Lipopolysccaride Binding Protein (LBP) is a 58KD glycoprotein produced in liver. It binds at lipid A of LPS with high affinity (10-9M) and reduced the cellular LPS effects at CD14+ cells (IL1ß, IL6, TNFα). It acts as opsonin for GRAM negative cells, LPS, neutrophiles and granulocytes.

Molecular Weight: ~58kDa

Gene ID: 16803

UniProt: Q61805

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process