AVEN antibody (AA 254-362)

Catalog No. ABIN336088

Product Details anti-AVEN Antibody

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Binding Specificity: AA 254-362

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This AVEN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes AVEN / PDCD12.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse.

Characteristics: Synonyms: PDCD12, Cell death regulator Aven, Programmed cell death 12

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human PDCD12 (aa 254-362) purified from E. coli

Clone: 3G4

Isotype: IgG2a

Application Details

Application Notes: ELISA. Western blot (1: 1,000 - 1: 3,000). Immunohistochemistry on paraffin sections (1: 50 - 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for AVEN

Target: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Alternative Name: AVEN (AVEN Products)

Synonyms: AVEN antibody, pdcd12 antibody, aven antibody, wu:fc08c09 antibody, si:ch211-150c22.4 antibody, PDCD12 antibody, 1700013A01Rik antibody, 1700056A21Rik antibody, mAven-L antibody, mAven-S antibody, apoptosis and caspase activation inhibitor antibody, apoptosis, caspase activation inhibitor L homeolog antibody, apoptosis, caspase activation inhibitor antibody, Aven antibody, AVEN antibody, aven.L antibody, aven antibody

Background: PDCD12 (Programmed cell death 12), also referred to as AVEN, represents a new class of cell death regulator. PDCD12 is a conserved intracellular membrane protein that blocks apoptosis impeded by Apaf-1 mediated caspase activation. Bcl-2 and BAD also interact with PDCD12 to prevent apoptosis. It is expressed in a wide variety of normal tissues including heart, skeletal muscle, kidney, liver, testis, and diseases such as cancer.Synonyms: Cell death regulator Aven, PDCD12, Programmed cell death 12

Gene ID: 57099

UniProt: Q9NQS1