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CHEK1 antibody
CHEK1
Reactivity: Human, Mouse
WB, ELISA
Host: Mouse
Monoclonal
2G1D5
unconjugated
Product Details anti-CHEK1 Antibody
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Target
See all CHEK1 Antibodies
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Reactivity
All reactivities for CHEK1 antibodies
Human, Mouse
Host
All hosts for CHEK1 antibodies
Mouse
Clonality
All clonalities for CHEK1 antibodies
Monoclonal
Conjugate
All conjugates for CHEK1 antibodies
This CHEK1 antibody is un-conjugated
Application
All applications for CHEK1 antibodies
Western Blotting (WB), ELISA
Cross-Reactivity
Mouse (Murine)
Purification
Purified antibody.
Immunogen
CHK1 antibody was raised in Mouse using a purified recombinant fragment of CHK1 expressed in E. coli as the immunogen.
Clone
2G1D5
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
ELISA: 1:10,000, WB: 1:500-1:2,000 Optimal conditions should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
Lot specific
Buffer
Purified antibody supplied in PBS containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freeze/thaw cycles. Dilute only prior to immediate use.
Storage
4 °C/-20 °C
Storage Comment
Store at 4 °C for short term storage. Store at -20 °C for long term storage.
Target Details for CHEK1
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Target
CHEK1
(Checkpoint Kinase 1 (CHEK1))
Alternative Name
CHK1 (CHEK1 Products )
Synonyms
An08g10320 antibody, AO090003000441 antibody, CHK1 antibody, chk1 antibody, C85740 antibody, Chk1 antibody, rad27 antibody, id:ibd2720 antibody, zgc:56093 antibody, CHEK1 antibody, checkpoint kinase 1 antibody, serine/threonine-protein kinase chk1 antibody, serine/threonine-protein kinase Chk1 antibody, CAMK/CAMKL/CHK1 protein kinase Chk1 antibody, checkpoint kinase 1 S homeolog antibody, CHEK1 antibody, ANI_1_2436074 antibody, AOR_1_768154 antibody, PTRG_04183 antibody, SJAG_01680 antibody, PAAG_04978 antibody, MCYG_03290 antibody, VDBG_03742 antibody, chek1.S antibody, Chek1 antibody, chek1 antibody
Background
CHK1 is a kinase that phosphorylates Cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Synonyms: Monoclonal CHK1 antibody, Anti-CHK1 antibody, CHK-1 antibody, CHK 1 antibody, CHEK1 antibody.
Pathways
p53 Signaling , Apoptosis , Cell Division Cycle , DNA Damage Repair
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