This antibody recognises an internal region of stromal interaction molecule-2 (STIM2), a ubiquitously expressed type I membrane protein, of which at least three isoforms have been identified.
Purification
Purified
Immunogen
A 17 amino acid peptide located near the centre of human STIM2.
Stim2
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Application Notes
Western Blot: 0.5 - 1.0 μg/mL, detects a band of approximately 105 kDa in A20 cell lysates Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
In T-lymphocytes and other haematopoietic cells, the mechanism for increasing intracellular Ca2+, following antigen mediated T-cell activation, is through the store-operated Ca2+ release-activated Ca2+ (CRAC) channels. STIM1 is reported to activate CRAC channels upon Ca2+ depletion. Whereas, STIM2 acts to inhibit the STIM1-mediated store-operated Ca2+ entry, and forms complexes with STIM1, suggesting that these molecules may play a co-ordinated role in controlling Ca2+ entry.Synonyms: KIAA1482, Stromal interaction molecule 2