SH2B3
Reactivity: Human
WB, IF (cc), IF (p)
Host: Rabbit
Polyclonal
AbBy Fluor® 680
Application Notes
Western Blot: 0.3 - 1.0g/mL, detects a band of approximately 70 kDa in human MOLT4 celllysates. (Predicted Mwt.63.0 kDa) Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5mg/mL
Buffer
TRIS buffered saline containing 0.02 % Sodium Azide and 0.5 % Bovine Serum Albumin
Preservative
Sodium azide
Precaution of Use
This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
LNK is an SH2-containing adaptor protein, which regulates cytokine receptor-mediated and growth factor pathways, and plays an essential role in B cell lymphopoiesis. LNK mRNA is preferentially expressed in lymph node and spleen lymphocytes and the expression of LNK in vascular endothelial cells (ECs), increases in response to TNFalpha. The role of LNK as a negative regulator, includes the down regulation of the pro-inflammatory molecules VCAM-1 and E-selectin induced by TNFalpha, modulation of P13-kinase and MAPK ERK1/2 activity, and negative regulation of Thrombopoietin-mediated cell proliferation and endomitosis in hematopoietic cell lines.Synonyms: LNK, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, SH2B adapter protein 3, SH2B3, Signal transduction protein Lnk