Uromodulin antibody (AA 329-378)

Catalog No. ABIN3180922

Product Details anti-Uromodulin Antibody

Target: Uromodulin (UMOD)

Binding Specificity: AA 329-378

Reactivity: Please inquire

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Uromodulin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purpose: Rabbit polyclonal antibody anti-Uromodulin (329-378 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.

Specificity: THP Polyclonal Antibody detects endogenous levels of THP protein.

Characteristics: Rabbit Polyclonal to THP.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized peptide derived from the human THP at the amino acid range 329-378

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:10000, IHC-P 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: -20 °C

Storage Comment: Store at -20°C.

Target Details for Uromodulin

Target: Uromodulin (UMOD)

Alternative Name: UMOD (UMOD Products)

Synonyms: ADMCKD2 antibody, FJHN antibody, HNFJ antibody, HNFJ1 antibody, MCKD2 antibody, THGP antibody, THP antibody, urehr4 antibody, uromodulin antibody, UMOD antibody, Umod antibody

Background: Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. Protects against urinary tract infections by binding to type 1 fimbriated E.coli. Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation. Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens.

Molecular Weight: 70 kDa

Gene ID: 7369

UniProt: P07911