SLC16A3
Reactivity: Human
Host: Rabbit
Polyclonal
FITC
Application Notes
ELISA: 1/40000-1/60000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1.0 mg/mL
Buffer
Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target
SLC16A3
(Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 3 (SLC16A3))
MCT 3 antibody, MCT 4 antibody, MCT-3 antibody, MCT-4 antibody, MCT3 antibody, MCT4 antibody, mct antibody, slc16a3b antibody, Mct3 antibody, Mct4 antibody, MCT4b antibody, wu:fd20b02 antibody, wu:fi38f12 antibody, zgc:55905 antibody, solute carrier family 16 member 3 antibody, solute carrier family 16 member 3 L homeolog antibody, solute carrier family 16 (monocarboxylic acid transporters), member 3 antibody, solute carrier family 16 (monocarboxylate transporter), member 3 antibody, SLC16A3 antibody, slc16a3.L antibody, Slc16a3 antibody, slc16a3 antibody
Background
Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs),which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCTs in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.Synonyms: MCT 3, MCT 4, MCT3, MCT4, Monocarboxylate transporter 3, Monocarboxylate transporter 4, Solute carrier family 16 member 3