TSC22D1
Reactivity: Human, Rat, Mouse
WB, ELISA, IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.Synonyms: Cerebral protein 2, KIAA1994, Regulatory protein TSC-22, TGFB-stimulated clone 22 homolog, TGFB1I4, TSC22, TSC22 domain family protein 1, Transforming growth factor beta-1-induced transcript 4 protein