Serotonin Receptor 4 antibody
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- Target See all Serotonin Receptor 4 (HTR4) Antibodies
- Serotonin Receptor 4 (HTR4)
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Serotonin Receptor 4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificity
- This antibody detects endogenous levels of Serotonin Receptor 4 (SR-4) protein.(region surrounding asn180)
- Purification
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product HTR4 Primary Antibody
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- Application Notes
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ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Serotonin Receptor 4 (HTR4)
- Alternative Name
- Serotonin Receptor 4 / HTR4 (HTR4 Products)
- Synonyms
- 5-HT4 antibody, 5-HT<4L> antibody, 5HTR4 antibody, 5-HT4S antibody, 5-HT4R antibody, 5 hydroxytryptamine (serotonin) receptor 4 antibody, 5-hydroxytryptamine receptor 4 antibody, Htr4 antibody, HTR4 antibody
- Background
- Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. SR-3 is a ligand-gated ion channel, whereas all other known serotonin receptor subtypes are G protein-coupled receptors. The gene which encodes SR-3 maps to human chromosome 11q23.1-q23.2. SR-4 mediates widespread effects in central and peripheral nervous systems. The gene which encodes SR-4 maps to human chromosome 5q31-q33. SR-7 belongs to the superfamily of G protein-coupled receptors. The gene which encodes SR-7 maps to human chromosome 10q21-q24.Synonyms: 5-HT-4, 5-HT4, 5-hydroxytryptamine receptor 4
- Gene ID
- 3360
- NCBI Accession
- NP_000861
- UniProt
- Q13639
- Pathways
- JAK-STAT Signaling, cAMP Metabolic Process, S100 Proteins
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