CD38 antibody (Biotin)

Catalog No. ABIN3071825

Product Details anti-CD38 Antibody (Biotin)

Target: CD38

Reactivity: Human, Baboon, Cynomolgus, Rhesus Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD38 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Purpose: CD38 Biotin Antibody

Characteristics: The clone OKT10, a mouse monoclonal antibody, recognizes a 45 kDa, type II transmembrane cell surface glycoprotein known as CD38. The CD38 antigen is expressed on pre-B lymphocytes, plasma cells, thymocytes and monocytes. CD38 also presents on activated T lymphocytes, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. Antigen expression is detected during the early stage of T- and B-lymphocyte differentiation, then lost during the intermediate stage of maturation, only to reappear during the final stage of maturation. The CD38 antigen is expressed on 90 % of CD34+ cells and is not expressed on pluripotent stem cells. CD38 is expressed in T- and B-acute lymphoblastic leukemia (ALL), Burkitt's lymphoma, multiple myeloma, acute myeloid leukemia (AML), and chronic lymphocytic leukemia (CLL).

Purification: Purified

Purity: >95 %

Grade: GMP Grade

Immunogen: Human acute lymphoblastic leukaemia cells

Clone: OKT10

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS pH 7.2, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

References for anti-CD38 antibody (Biotin) (ABIN3071825)

Hammarlund, Thomas, Amanna, Holden, Slayden, Park, Gao, Slifka: "Plasma cell survival in the absence of B cell memory." in: Nature communications, Vol. 8, Issue 1, pp. 1781, (2018) (PubMed).

Target Details for CD38

Target: CD38

Abstract: CD38 Products

Synonyms: T10 antibody, Cd38-rs1 antibody, cd38 antibody, ADPRC 1 antibody, cADPr hydrolase 1 antibody, CD38 molecule antibody, CD38 antigen antibody, CD38 molecule L homeolog antibody, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 antibody, CD38 antibody, Cd38 antibody, cd38.L antibody

NCBI Accession: NM_001775

UniProt: P28907