CERS6 antibody
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- Target See all CERS6 Antibodies
- CERS6 (Ceramide Synthase 6 (CERS6))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CERS6 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human
- Characteristics
- LAG1 longevity assurance homolog 6,Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.
- Purification
- Ammonium Sulfate Precipitation
- Immunogen
- Synthetic peptide dervied from human Lass6 protein
- Top Product
- Discover our top product CERS6 Primary Antibody
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- Application Notes
- Antibody can be used for Western blotting (5-7 μg/mL). Optimal concentration should be evaluated by serial dilutions.
- Restrictions
- For Research Use only
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- Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Target
- CERS6 (Ceramide Synthase 6 (CERS6))
- Alternative Name
- Lass6 (CERS6 Products)
- Synonyms
- si:ch211-278b7.1 antibody, CERS6 antibody, CERS5 antibody, LASS6 antibody, 4732462C07Rik antibody, AW544719 antibody, Lass6 antibody, T1L antibody, RGD1561599 antibody, ceramide synthase 6 antibody, CERS6 antibody, cers6 antibody, Cers6 antibody
- UniProt
- Q6ZMG9
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