HIRA antibody

Catalog No. ABIN306897

Product Details anti-HIRA Antibody

Target: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivity: Saccharomyces cerevisiae

Host: Mouse

Clonality: Monoclonal

Conjugate: This HIRA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 4B9

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blotting (5-10 ug/ml). Positive Control: Mav108 cells expressing recombinant TUP1 protein.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/ml

Storage: -20 °C

Target Details for HIRA

Target: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Alternative Name: TUP1 (HIRA Products)

Background: Yeast Tup 1p-Ssn6p repressor complex represents a novel paradigm for transcriptional repression and for the role of chromatin in repression. TUP 1 and SSN6 are involved in repression of several diverse families of genes in yeast, including cell type-specific genes regulated by the alphga2 and a1/alpha2 repressors. Ssn6-Tupl interacts with class I histone deacetylases required for repression, and rfecrfuitment of yeast Tuplp-Ssn6p repressor is associated with localized decreases in histone acetylation. Synonyms: General transcriptional corepressor TUP1, Glucose repression regulatory protein TUP1, Flocculation suppressor protein, Repressor AER2, TUP1, AAR1, AER2, AMM1, CYC9, FLK1, SFL2, UMR7, YCR084C, YCR84.

UniProt: P16649

Pathways: Chromatin Binding