Kv1.1 Potassium Channel antibody

Catalog No. ABIN306869

Product Details anti-Kv1.1 Potassium Channel Antibody

Target: Kv1.1 Potassium Channel

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Kv1.1 Potassium Channel antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Voltage-Gated Potassium Channel, Kv1.1 isoform,K+ channels from the Kv1 subfamily contain four alpha-subunits and the combinations (from Kv1.1-1.6) determine susceptibility to dendrotoxin (DTX) homologue. Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed in a variety of neurons in adult rodents, in which it appears to be involved in regulating neuronal excitability. Here we show that Kv1.1 is also expressed during embryonic development in the mouse, exhibiting two transient peaks of expression around embryonic day 9.5 (E9.5) and E14.5. Potassium channels play a critical role in limiting neuronal excitability. Mutations in certain voltage-gated potassium channels have been associated with hyperexcitable phenotypes in both humans and animals. However, only recently have mutations in potassium channel genes (i.e. KCNQ2 and KCNQ3) been discovered in a human epilepsy, benign familial neonatal convulsions.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from the rat Kv1.1 potassium channel conjugated to KLH

Isotype: IgG

Application Details

Application Notes: This antibody can be used for Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for Kv1.1 Potassium Channel

Target: Kv1.1 Potassium Channel

Abstract: Kv1.1 Potassium Channel Products