p53 antibody (AA 371-380)
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- Target See all p53 (TP53) Antibodies
- p53 (TP53) (Tumor Protein P53 (TP53))
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Binding Specificity
- AA 371-380
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This p53 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
- Cross-Reactivity
- Human, Monkey, Mouse, Rat
- Characteristics
- p53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.
- Purification
- Protein A/G Chromatography
- Immunogen
- Hybridoma produced by the fusion of splenocytes from immunized with full length human p53 protein and mouse myeloma cells.
- Clone
- HR231
- Isotype
- IgG2b
- Top Product
- Discover our top product TP53 Primary Antibody
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- Application Notes
- This antibody can be used for Western blotting (1-5 μg/mL), immunoprecipitation, ELISA and immunohistochemistry. Optimal concentration should be evaluated by serial dilutions.
- Restrictions
- For Research Use only
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- Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Target
- p53 (TP53) (Tumor Protein P53 (TP53))
- Alternative Name
- p53 (TP53 Products)
- Synonyms
- BCC7 antibody, LFS1 antibody, P53 antibody, TRP53 antibody, p53 antibody, Trp53 antibody, brp53 antibody, drp53 antibody, etID22686.5 antibody, fb40d06 antibody, wu:fb40d06 antibody, zgc:111919 antibody, Tp53 antibody, bbl antibody, bfy antibody, bhy antibody, p44 antibody, tp53 antibody, Xp53 antibody, TP53 antibody, tumor protein p53 antibody, cellular tumor antigen p53 antibody, transformation related protein 53 antibody, tumor protein p53 L homeolog antibody, TP53 antibody, CpipJ_CPIJ002758 antibody, Tp53 antibody, tp53 antibody, Trp53 antibody, tp53.L antibody
- UniProt
- Q9BRQ8
- Pathways
- p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
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