EPH Receptor B1 antibody (AA 620-1596)

Catalog No. ABIN306670

Product Details anti-EPH Receptor B1 Antibody

Target: EPH Receptor B1 (EPHB1)

Binding Specificity: AA 620-1596

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Rat

Characteristics: Eph B1 (ELK receptor) SAM, Tyrosine-protein kinase receptor EPH-2, Ephrin type B receptor 1, HEK6,Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicated during the process of spermiogenesis and in the actin-based stellate morphology of mesangial cells

Purification: Ammonium Sulfate Precipitation

Immunogen: Sheep were immunized with a recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blot (2-5 μg/mL), immunohistochemistry and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: ELK rec tyr Kinase (Eph B1 SAM) (EPHB1 Products)

Pathways: RTK Signaling