Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

TPP1 antibody (Middle Region)

TPP1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044554
  • Target See all TPP1 Antibodies
    TPP1 (Tripeptidyl Peptidase I (TPP1))
    Binding Specificity
    • 15
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 227-261, Middle Region
    Reactivity
    • 65
    • 26
    • 11
    Human
    Host
    • 60
    • 5
    • 1
    Rabbit
    Clonality
    • 63
    • 3
    Polyclonal
    Conjugate
    • 28
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TPP1 antibody is un-conjugated
    Application
    • 51
    • 26
    • 13
    • 13
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Tripeptidyl-peptidase 1(TPP1) detection. Tested with WB, IHC-P in Human.
    Sequence
    CAQFLEQYFH DSDLAQFMRL FGGNFAHQAS VARVV
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Tripeptidyl-peptidase 1(TPP1) detection. Tested with WB, IHC-P in Human.
    Gene Name: tripeptidyl peptidase I
    Protein Name: Tripeptidyl-peptidase 1
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human TPP1 (227-261aa CAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVV), different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TPP1 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Target
    TPP1 (Tripeptidyl Peptidase I (TPP1))
    Alternative Name
    TPP1 (TPP1 Products)
    Synonyms
    cln2 antibody, fa01b09 antibody, im:7149243 antibody, wu:fa01b09 antibody, CLN2 antibody, LPIC antibody, TPP-1 antibody, TPP-I antibody, Cln2 antibody, tripeptidyl peptidase I antibody, tripeptidyl-peptidase 1 antibody, tripeptidyl peptidase 1 antibody, tpp1 antibody, NAEGRDRAFT_78259 antibody, MCYG_00184 antibody, MGYG_05881 antibody, MGYG_00757 antibody, TPP1 antibody, Tpp1 antibody
    Background
    Tripeptidyl-peptidase 1, also known as Lysosomal pepstatin-insensitive protease, is an enzyme that in humans is encoded by the TPP1 gene. This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

    Synonyms: Cell growth inhibiting gene 1 protein antibody|Cell growth-inhibiting gene 1 protein antibody|Ceroid lipofuscinosis neuronal 2 antibody|Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease) antibody|Ceroid lipofuscinosis neuronal 2 late infantile antibody|CLN 2 antibody|CLN2 antibody|GIG 1 antibody|GIG1 antibody|Growth inhibiting protein 1 antibody|LPIC antibody| Lysosomal pepstatin insensitive protease antibody|Lysosomal pepstatin-insensitive protease antibody|MGC21297 antibody|TPP 1 antibody| TPP I antibody|TPP-1 antibody|TPP-I antibody|Tpp1 antibody|TPP1_HUMAN antibody|TPPI antibody|Tripeptidyl aminopeptidase antibody| Tripeptidyl peptidase I antibody|Tripeptidyl-peptidase 1 antibody|Tripeptidyl-peptidase I antibody
    Gene ID
    1200
    UniProt
    O14773
    Pathways
    Cell Division Cycle, ER-Nucleus Signaling
You are here:
Support