FcRn antibody (AA 56-291)

Catalog No. ABIN3044521

Product Details anti-FcRn Antibody

Target: FcRn (IgG receptor FcRn (FcRn))

Binding Specificity: AA 56-291

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for IgG receptor FcRn large subunit p51(FCGRT) detection. Tested with WB, IHC-P in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for IgG receptor FcRn large subunit p51(FCGRT) detection. Tested with WB, IHC-P in Human.
Gene Name: Fc fragment of IgG receptor and transporter
Protein Name: IgG receptor FcRn large subunit p51

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2% and 68.9% amino acid (aa) sequence identity with mouse and rat FCGRT, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for FcRn

Target: FcRn (IgG receptor FcRn (FcRn))

Alternative Name: FCGRT (FcRn Products)

Synonyms: FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody

Background: IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. In addition, it is postulated that long-range cis inactivation of the FCGRT gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The FCGRT gene is closely situated to the DMPK gene, which is mutant in DM.

Synonyms: Alpha chain antibody|Fc fragment of IgG, receptor transporter, alpha antibody|FCGRN_HUMAN antibody|FCGRT antibody|FcRn alpha chain antibody|FcRn antibody|FCRN, alpha chain antibody|IgG Fc fragment receptor transporter alpha chain antibody|IgG Gc receptor antibody| IgG receptor FcRn large subunit p51 antibody|IgG receptor FcRn large subunit p51 precursor antibody|Immunoglobulin receptor, intestinal, heavy chain antibody|Neonatal Fc receptor antibody

Gene ID: 2217

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process