PARK7/DJ1 antibody (AA 2-189)
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- Target See all PARK7/DJ1 (PARK7) Antibodies
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
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Binding Specificity
- AA 2-189
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PARK7/DJ1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Rabbit IgG polyclonal antibody for Protein deglycase DJ-1(PARK7) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Protein deglycase DJ-1(PARK7) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: parkinson protein 7
Protein Name: Protein deglycase DJ-1 - Purification
- Immunogen affinity purified.
- Immunogen
- E.coli-derived human PARK7 recombinant protein (Position: A2-D189). Human PARK7 shares 91% amino acid (aa) sequence identity with both mouse and rat PARK7.
- Isotype
- IgG
- Top Product
- Discover our top product PARK7 Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for PARK7 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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- Target
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
- Alternative Name
- PARK7 (PARK7 Products)
- Synonyms
- DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody
- Background
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Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.
Synonyms: CAP1 antibody|DJ 1 antibody|DJ-1 antibody|DJ1 antibody|DJ1 protein antibody|FLJ27376 antibody|FLJ34360 antibody|FLJ92274 antibody|Oncogene DJ1 antibody|OTTHUMP00000001348 antibody|OTTHUMP00000001349 antibody|OTTHUMP00000001350 antibody|OTTHUMP00000001351 antibody|Park 7 antibody|Park7 antibody|PARK7_HUMAN antibody|Parkinson disease (autosomal recessive early onset) 7 antibody|Parkinson disease (autosomal recessive, early onset) 7 antibody|Parkinson disease protein 7 antibody|Parkinson protein 7 antibody|Protein DJ 1 antibody|Protein DJ-1 antibody|RNA binding protein regulatory subunit antibody|RS antibody|SP22 antibody - Gene ID
- 11315
- UniProt
- Q99497
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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