SMC3 antibody (C-Term)

Catalog No. ABIN3043343

Product Details anti-SMC3 Antibody

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Binding Specificity: AA 1178-1216, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for Structural maintenance of chromosomes protein 3(SMC3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequence: ELLESADKFY GVKFRNKVSH IDVITAEMAK DFVEDDTTH

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Structural maintenance of chromosomes protein 3(SMC3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: structural maintenance of chromosomes 3
Protein Name: Structural maintenance of chromosomes protein 3

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human SMC3 (1178-1216aa ELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTH), identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for SMC3

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Alternative Name: SMC3 (SMC3 Products)

Synonyms: cspg6 antibody, xsmc3 antibody, BAM antibody, BMH antibody, CDLS3 antibody, CSPG6 antibody, HCAP antibody, SMC3L1 antibody, Bamacan antibody, Cspg6 antibody, Mmip1 antibody, SMC-3 antibody, SmcD antibody, im:7142991 antibody, wu:fb22e01 antibody, wu:fc30d07 antibody, bamacan antibody, structural maintenance of chromosomes 3 antibody, structural maintenance of chromosomes 3 S homeolog antibody, smc3 antibody, SMC3 antibody, Smc3 antibody, smc3.S antibody

Background: Structural maintenance of chromosomes 3, also known as SMC3, is a human gene. This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Synonyms: BAM antibody|Bamacan antibody|Basement membrane associated chondroitin proteoglycan antibody|Basement membrane-associated chondroitin proteoglycan antibody|BMH antibody|CDLS3 antibody|chondroitin sulfate proteoglycan 6 (bamacan) antibody|Chondroitin sulfate proteoglycan 6 antibody|Chromosome associated polypeptide antibody|Chromosome-associated polypeptide antibody|CSPG 6 antibody|CSPG6 antibody|hCAP antibody|SMC 3 antibody|SMC protein 3 antibody|SMC-3 antibody|smc3 antibody|SMC3_HUMAN antibody|SMC3L1 antibody| Structural maintenance of chromosome 3 antibody|Structural maintenance of chromosomes 3 antibody|Structural maintenance of chromosomes protein 3 antibody

Gene ID: 9126

Pathways: Stem Cell Maintenance