Patched 2 antibody (C-Term)

Catalog No. ABIN3043014

Product Details anti-Patched 2 Antibody

Target: Patched 2 (PTCH2)

Binding Specificity: AA 885-901, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Patched 2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Protein patched homolog 2(PTCH2) detection. Tested with WB in Human,Mouse.

Sequence: WLHDKYDTTG ENLRIPP

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Protein patched homolog 2(PTCH2) detection. Tested with WB in Human,Mouse.
Gene Name: patched 2
Protein Name: Protein patched homolog 2(PTC2)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2(885-901aa WLHDKYDTTGENLRIPP), different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Patched 2

Target: Patched 2 (PTCH2)

Alternative Name: PTCH2 (PTCH2 Products)

Synonyms: PTC2 antibody, ptc2 antibody, Ptch1 antibody, ptc-2 antibody, xptc-2 antibody, xptch-2 antibody, patched-2 antibody, ptch2 antibody, ptc-1 antibody, ptc1 antibody, ptch1 antibody, patched 2 antibody, patched 2 S homeolog antibody, patched 2 L homeolog antibody, PTCH2 antibody, Ptch2 antibody, ptch2.S antibody, ptch2.L antibody, ptch2 antibody

Background: PTCH2(patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling.

Synonyms: patched(Drosophila) homolog 2 antibody|patched homolog 2(Drosophila) antibody|Protein patched homolog 2 antibody|PTC2 antibody|PTC2_HUMAN antibody|Ptch2 antibody

UniProt: Q9Y6C5

Pathways: Hedgehog Signaling