HSD17B10 antibody (AA 48-261)

Catalog No. ABIN3042460

Product Details anti-HSD17B10 Antibody

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Binding Specificity: AA 48-261

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HSD17B10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for 3-hydroxyacyl-CoA dehydrogenase type-2(HSD17B10) detection. Tested with WB, IHC-P in Human,Mouse.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for 3-hydroxyacyl-CoA dehydrogenase type-2(HSD17B10) detection. Tested with WB, IHC-P in Human,Mouse.
Gene Name: hydroxysteroid (17-beta) dehydrogenase 10
Protein Name: 3-hydroxyacyl-CoA dehydrogenase type-2

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ERAB recombinant protein (Position: E48-P261). Human ERAB shares 87% and 88% amino acid (aa) sequence identity with mouse and rat ERAB, respectively.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, The detection limit for ERAB is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Alternative Name: HSD17B10 (HSD17B10 Products)

Synonyms: hadh2 antibody, im:6899159 antibody, wu:fj61f03 antibody, zgc:101605 antibody, abad antibody, camr antibody, erab antibody, hcd2 antibody, hsd10 antibody, mhbd antibody, mrpp2 antibody, mrx17 antibody, mrx31 antibody, mrxs10 antibody, schad antibody, sdr5c1 antibody, HADH2 antibody, HSD17B10 antibody, 17b-HSD10 antibody, ABAD antibody, CAMR antibody, DUPXp11.22 antibody, ERAB antibody, HCD2 antibody, MHBD antibody, MRPP2 antibody, MRX17 antibody, MRX31 antibody, MRXS10 antibody, SCHAD antibody, SDR5C1 antibody, 17bHSD10 antibody, Ads9 antibody, Hadh2 antibody, hydroxysteroid (17-beta) dehydrogenase 10 antibody, hydroxysteroid 17-beta dehydrogenase 10 antibody, hydroxysteroid (17-beta) dehydrogenase 10 L homeolog antibody, HSD17B10 antibody, hsd17b10 antibody, hsd17b10.L antibody, Hsd17b10 antibody

Background: ERAB is also known as HSD17B10 or HADH2. This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Synonyms: 17 beta hydroxysteroid dehydrogenase 10 antibody|17 beta hydroxysteroid dehydrogenase type 10 antibody|17-beta-HSD 10 antibody|17-beta-hydroxysteroid dehydrogenase 10 antibody|17b HSD10 antibody|3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody|3 hydroxyacyl CoA dehydrogenase type 2 antibody|3 hydroxyacyl CoA dehydrogenase type II antibody|3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody|3-hydroxyacyl-CoA dehydrogenase type II antibody|3-hydroxyacyl-CoA dehydrogenase type-2 antibody|AB binding alcohol dehydrogenase antibody|ABAD antibody|Ads9 antibody|Amyloid beta binding polypeptide antibody|Amyloid beta peptide binding alcohol dehydrogenase antibody|Amyloid beta peptide binding protein antibody|CAMR antibody|DUPXp11.22 antibody|Endoplasmic Reticulum Amyloid Binding Protein antibody|Endoplasmic reticulum associated amyloid beta peptide binding protein antibody|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody|ER associated amyloid beta-binding protein antibody|ERAB antibody|HADH 2 antibody|HADH2 antibody|HCD 2 antibody|HCD2 antibody|HCD2_HUMAN antibody|Hsd17b10 antibody|Hydroxyacyl CoA Dehydrogenase type II antibody|Hydroxyacyl Coenzyme A dehydrogenase type II antibody|Hydroxysteroid (17 beta) dehydrogenase 10 antibody|Mental retardation X linked syndromic 11 antibody|MHBD antibody|Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody|Mitochondrial ribonuclease P protein 2 antibody|Mitochondrial RNase P protein 2 antibody|MRPP2 antibody|MRX17 antibody|SCHAD antibody|SDR5C1 antibody|Short chain dehydrogenase/reductase family 5C member 1 antibody|Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody|Short chain type dehydrogenase/reductase XH98G2 antibody|Short-chain type dehydrogenase/reductase XH98G2 antibody|Type 10 17b HSD antibody|Type 10 17beta hydroxysteroid dehydrogenase antibody|Type II HADH antibody|XH98G2 antibody

Gene ID: 3028

UniProt: Q99714