FURIN antibody (AA 591-794)

Catalog No. ABIN3042409

Product Details anti-FURIN Antibody

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Binding Specificity: AA 591-794

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FURIN antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Furin(FURIN) detection. Tested with WB in Human.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Furin(FURIN) detection. Tested with WB in Human.
Gene Name: furin (paired basic amino acid cleaving enzyme)
Protein Name: Furin

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Furin recombinant protein (Position: T591-L794). Human Furin shares 88% amino acid (aa) sequence identity with both mouse and rat Furin.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for Furin is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for FURIN

Target: FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))

Alternative Name: FURIN (FURIN Products)

Synonyms: FURIN antibody, furin antibody, si:dkey-281a24.5 antibody, FUR antibody, LOC100220259 antibody, PACE antibody, spc1 antibody, xfurin antibody, MGC82710 antibody, PCSK3 antibody, SPC1 antibody, 9130404I01Rik antibody, Fur antibody, Pcsk3 antibody, Pace antibody, furin, paired basic amino acid cleaving enzyme antibody, furin (paired basic amino acid cleaving enzyme) a antibody, furin (paired basic amino acid cleaving enzyme) b antibody, furin, paired basic amino acid cleaving enzyme L homeolog antibody, furin (paired basic amino acid cleaving enzyme) antibody, FURIN antibody, furina antibody, furinb antibody, furin antibody, furin.L antibody, Furin antibody

Background: Furin(Fur), also known as PACE, is a protein that in humans is encoded by the FURIN gene. The protein encoded by this gene is an enzyme which belongs to the subtilisin-like proprotein convertase family. The Furin gene is located approximately 1 kb upstream of the FES gene on chromosome 15q25-q26. This gene is thought to play a role in tumor progression. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance.

Synonyms: Dibasic processing enzyme antibody|Dibasic-processing enzyme antibody|FES upstream region antibody|FUR antibody|FURIN antibody|Furin membrane associated receptor protein antibody|FURIN_HUMAN antibody|PACE antibody|Paired basic amino acid residue cleaving enzyme antibody|Paired basic amino acid residue-cleaving enzyme antibody|PCSK3 antibody|Proprotein convertase subtilisin/kexin type 3 antibody|SPC1 antibody

Gene ID: 5045

UniProt: P09958

Pathways: Notch Signaling, Neurotrophin Signaling Pathway